Sundowning, sometimes called Sundown Syndrome, is the label given to late day anxiety, irritability, disorientation and general agitation in people with Alzheimer’s. Sundowning frustrates home caregivers and professional care staff alike, as they often feel completely unable to comfort the person affected. Researchers and care staff alike are looking for answers. One nursing home in particular has made some dramatic changes in end-of-day care, resulting in a major reduction in the need to medicate residents for late day anxiety. Home caregivers can learn from their work, as well.